Liverpool last won at the Etihad in 2018, a 2-1 Champions League quarter-final victory, but they haven't toppled Man City on their own turf since 2015 in the Premier League.
While that was a 4-1 thrashing in the early days of Jurgen Klopp's reign - Martin Skrtel and Philippe Coutinho among the goals - Pep Guardiola was yet to take residence in the Man City dugout.
Liverpool lost twice at the Etihad last season - a 3-2 defeat in the Carabao Cup before a 4-1 hammering in the league last April. All things considered, the signs are not too positive for Liverpool ahead of their trip to Manchester.
However, one remarkable stat gives the Reds hope of pulling off what would arguably be a surprising result on Saturday.
If Man City were to beat Liverpool at the weekend, it would be the first time that the Cityzens had won consecutive league matches against the Reds since 1937.
Just before World War II, Man City won four consecutive matches against Liverpool in the league in a period of rare sky blue dominance.
However, despite all the phenomenal players they have welcomed through the doors at the Etihad since the arrival of the Abu Dhabi cash, they have still been unable to win successive league matches against the Reds.
By contrast, Liverpool last won successive league games against Man City back in 2016, having also done it the year before. In fact, it's been a regular occurrence for the Reds throughout the Premier League era.
Let's hope that Man City don't manage to change history on Saturday afternoon.