Conor Bradley will make his Premier League debut against AFC Bournemouth on Sunday afternoon.
The youngster fills in for Trent Alexander-Arnold at right-back, who is currently ruled out with a knee injury he picked up against Arsenal.
The Northern Irishman impressed in a recent start against Fulham in Liverpool's League Cup semi-final first leg, giving Reds fans hope that Bradley could be the man that allows Alexander-Arnold to permanently move into midfield.
He joins Ibrahima Konate, Virgil van Dijk and Joe Gomez in the defence that lines up against the Cherries, becoming the first Northern Irishman to play for Liverpool in the Premier League.
Jurgen Klopp does make two changes to the side that beat Fulham almost a fortnight ago - Alisson regains his place in the side from Caoimhin Kelleher, while Darwin Nunez returns to the attack alongside Diogo Jota and Luis Diaz.
It's also a notable day for Diaz, who makes his 50th Premier League appearance in a Liverpool shirt.
The midfield three of Alexis Mac Allister, Curtis Jones and Harvey Elliott remains unchanged from the Fulham contest.
Bradley won't be without any familiar faces from the academy, with Bobby Clark, Kaide Gordon, James McConnell, Owen Beck and Jarell Quansah all making up the numbers on the bench.