Pending further internal emergency conditions tests in collaboration with Liverpool City Council, the stadium's capacity is poised to reach an impressive 60,000 as Vincent Kompany's team take the short trip from east Lancashire for the 3pm kick-off.
The newly promoted side stand in the way of the Reds as they aim to bounce back from Sunday's 3-1 defeat at the hands of Arsenal in the capital.
Still work to be done
While the £80 million redevelopment of the Anfield Road end still isn't fully complete, the opening of hospitality spaces now pushes the capacity closer to the final target of over 61,000.
This latest development in the project signals a substantial revenue boost for the Reds. With the redevelopment of the stand, the club aims to enhance matchday income significantly in the upcoming seasons.
However, the new upper stand, which saw Anfield welcome 58,000 fans when it first (partially) opened in December, still requires finishing touches to the back rows of the upper tier and the away end before the project can be declared complete.
A 75-year-old record
That said, if all goes to plan and the hospitality sections open without incident, this could see Liverpool shattering a record that has endured since 1949.
The current record for the largest attendance at Anfield during a league game stands at 58,757, achieved during a 2-2 draw with Chelsea.
Now, with the final preparations under way, Liverpool are poised to surpass this decades-old benchmark and create a new chapter in the club's storied history and set a new standard for matchday experiences.